Seziyan was born to V. S. Rajagopal on April 28, 1923. He completed his master’s before entering politics. He married Dr. Prema Seziyan
Seziyan was a well-known writer in Tamil and has written numerous short stories and one-act plays. He joined the Dravida Munnetra Kazhagam at an early age. In 1962, he stood for election from Perambalur Lok Sabha constituency and was elected to the Lok Sabha or lower house of the Indian Parliament. He served as a Member of Parliament for Perambalur from 1962 to 1967.
In the 1967 Lok Sabha elections, Sezhiyan defeated two-time Congress MP C. R. Pattabhiraman from Kumbakonam.